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All medicines may cause side effects, but many people have no, or minor, side effects. after a preliminary stimulation of the respiratory centre, causing an increase in the rateand depth of respiration, it produces a depression which resultsin a decrease of the respirations followed by a total arrest. however, cardiac disease, by limiting blood flow to theliver, may impair disposition of those drugs whose metabolism isflow-limited (table 4-7). in addition, there was no evidence ofefficacy from any ofthe secondary analyses performed in this study. — on the intravenous injection of adrenaline a verymarked rise in the arterial blood-pressure occurs accompanied at firstby acceleration, then by slowing, and later again by acceleration of theheart. 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